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Isolation Precautions Compared

Standard, contact, droplet, airborne — the four precaution tiers in one grid, with the PPE, room type, and classic example pathogens, plus the aerosol-generating procedures that escalate respiratory care to airborne protection.

Written by Apex Respiratory Editorial Team

Educational use only. This material supports respiratory therapy education and exam review. It is not medical advice and is not a substitute for clinical judgment, institutional protocols, or physician orders. Always follow facility policies and current provider orders, and verify calculations independently before clinical use.

Standard & Transmission-Based Precautions

Comparison of standard, contact, droplet, and airborne isolation precautions with PPE, room type, and examples
PrecautionWhen It AppliesPPE RequiredRoomExamples
StandardAll patients, all care, all the timeHand hygiene; gloves, gown, mask, and eye protection as anticipated by exposureStandard roomApplied to every patient
ContactSpread by direct or indirect contactGloves and gownPrivate room preferredMRSA, VRE, Clostridioides difficile (soap-and-water hand hygiene), RSV, scabies
DropletSpread by large respiratory droplets over short distancesSurgical mask within about 6 feet, plus standard precautionsPrivate room preferred; door may remain openInfluenza, pertussis, Neisseria meningitidis, mumps, rubella
AirborneSpread by small airborne nuclei over long distancesFit-tested N95 or higher respiratorAirborne infection isolation room (negative pressure), door closedTuberculosis, measles (rubeola), varicella (chickenpox), disseminated zoster

How to Use This Chart

Transmission-based precautions are always layered on top of standard precautions — they add to the baseline, never replace it. Use the tier that matches the pathogen’s known route; when the route is uncertain, apply the higher tier until the organism is identified.

  • Standard precautions are the baseline for every patient; transmission-based precautions are layered on top.
  • Aerosol-generating procedures(intubation, open suctioning, bronchoscopy, NIV/high-flow, nebulizers, sputum induction, manual ventilation) raise airborne risk — use an N95 and a negative-pressure room per policy.
  • Clostridioides difficile and norovirusrequire soap-and-water hand washing — alcohol gel does not kill the spores.

Related Resources

Sources

  1. Siegel JD, Rhinehart E, Jackson M, Chiarello L; HICPAC. 2007 Guideline for Isolation Precautions: Preventing Transmission of Infectious Agents in Healthcare Settings. CDC; 2007 (updated 2019).
  2. Kacmarek RM, Stoller JK, Heuer AJ. Egan's Fundamentals of Respiratory Care. 12th ed. Elsevier; 2021. Infection control.